Since there isn’t any conclusive evidence to support the aforementioned risk, the best option is to consult one’s healthcare provider about the right dosage. To add to that, the Institute of Medicine has not established a tolerable upper intake level, which is the maximum daily intake of a nutrient that is unlikely to cause adverse health effects. However, these claims are yet to be substantiated with concrete scientific evidence due to the absence of large, controlled clinical trials. Concerns were raised regarding the long-term safety of the latter, after a study linked its use to possible DNA damage. They are considered to be the safer form with better bioavailability in comparison to chromium picolinate (CR-P), which is the form of chromium that is bound to picolinic acid. The niacin or nicotinic acid-bound chromium (Cr-N) supplements are widely used, as these have not been associated with toxicity. Ann de Wees Allen, the niacin-bound form is 672% and 311% better absorbed than chromium chloride and chromium picolinate respectively.Ĭhromium Polynicotinate Vs. The absorption rate of niacin-bound chromium polynicotinate is believed to be higher than the other two forms. The common supplemental sources include chromium chloride, chromium picolinate, and chromium polynicotinate. Generally, chromium supplementation or the inclusion of its dietary sources (whole grains, eggs, cheese, liver, lean meats, and brewer’s yeast) is recommended for treating its deficiency. Chromium losses might also increase in the event of physical stress, trauma, or acute infections. This is mainly attributed to the fact that processing of food leads to the removal of up to 80% of the chromium in foods. Though chromium is an essential trace element that is required in small amounts for the healthy functioning of the body, the incidence of chromium deficiency is quite high. Caution must be exercised by diabetics who are taking chromium supplements, as these can interact with the medication for diabetes, thereby increasing the risk of hypoglycemia. It is believed that chromium’s influence on insulin metabolism might be due to its interaction with a protein called low molecular weight chromium-binding substance (LMWCr).
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